Alpha-amylase activity inhibitors

专利名称：Alpha-amylase activity inhibitors发明人：Takashi Makino,Ritsuo Aiyama,Yoriko

Deguchi,Masaaki Watanuki,MasakoNakazawa,Harumi Mizukoshi,MasatoNagaoka,Katsuhisa Harada,Kuniko Osada

申请号：US10220280申请日：20021114

公开号：US20030124208A1公开日：20030703

摘要：The present invention relates to an &agr;-amylase activity inhibitor containing,as an effective component, polyphenols obtained through the following process: guavaleaves and/or guava fruit are subjected to extraction with one or more solvents selectedfrom among water and hydrophilic solvents; the resultant extract is subjected toultrafiltration, to thereby remove substances having a molecular weight of less than5,000; the remaining fraction is subjected to the butyl support hydrophobic

chromatography. The elution (flow rate: 1 mL/min) of the sample was accomplished withthe pH gradient by use of sodium dihydrogenphosphate and sodium phosphate solution(0.02 mol/L) and a fraction of the eluted substance is recovered, which fractioncorresponds to the third single peak of an elution curve which is obtained when theabsorbance of the substance is measured at 260 nm. The present invention also relatesto an &agr;-amylase activity inhibitor containing, as an effective component, polyphenolshaving specific physicochemical properties, and to food and beverages containing the&agr;-amylase activity inhibitor. The &agr;-amylase activity inhibitor of the present

invention exhibits remarkably excellent &agr;-amylase inhibitory activity as comparedwith guava extract. Accordingly, food and beverages containing the &agr;-amylase activityinhibitor are diet food and beverages suitable for people of high blood-sugar level orhyderlipidemia.

申请人：MAKINO TAKASHI,AIYAMA RITSUO,DEGUCHI YORIKO,WATANUKIMASAAKI,NAKAZAWA MASAKO,MIZUKOSHI HARUMI,NAGAOKA MASATO,HARADAKATSUHISA,OSADA KUNIKO

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