MODULATION OF IMMUNE RESPONSES

专利名称：MODULATION OF IMMUNE RESPONSES发明人：LANDAUER, Carl, John,DU PREEZ, Gabriel,

Johannes,SCHILLACK, Volker,

Reinhard,ATTFIELD, Derrick, Cecil,VAN DENBOGAERDE, Johannes, Beyers

申请号：EP946998.6申请日：19980916公开号：EP1019063A1公开日：20000719

摘要：A method of the stimulation or inhibition to immunocyte product are influencedor adjusted on external or endogenous immune stimulant immune response according toanimal, includes the steps that the compound for applying nontoxic immunomodulatoryeffective amount to this animal. Compound ein R1 selected from general chemicalformula (I) compound R 1-CO-NR2R3 WHER are selected from H and low (the i.e. groupthat C1 to C3) alkyl and C2 are formed to C3 alkenyls; R2 and R3 are identical or different,and the group each selected from H compositions, lower (i.e. C1 to C3). C1-C3) alkyl andC2-C3 alkenyls, these alkyl and the C2-C3 alkenyls property of can choose groundhalogenation or hydroxylating, or they can be bonded to each other from-(CH2) n-groups, wherein n is any number of 2-5 or group-(CH2) 2-O- (CH2) 2 and its metaboliteand prodrug. This method can be used for treating relevant to unsuitable immuneresponse various diseases, and the present invention provide formula (I) compoundmanufacture for treat the drug of this disease and pharmaceutical preparation containingfollowing substance in application: equally.

申请人：Frangold Holdings Limited

地址：Benstra Building,6th Floor,473B Cgurch Street Arcadia,Pretoria 0083 ZA

国籍：ZA

代理机构：Senior, Janet

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