专利名称：Laser microdissection and microarray
analysis of breast tumors reveal estrogenreceptor related genes and pathways
发明人：Yixin Wang,Jack X. Yu,Yugiu Jiang,Fei Yang申请号：US11398340申请日：20060404
公开号：US20080305959A1公开日：20081211
专利附图：
摘要：About 70% to 80% of breast cancers express estrogen receptor-α (ERα), andestrogens play important roles in the development and growth of hormone-dependent
tumors. Together with lymph node metastasis, tumor size and histological grade, ERstatus is considered one of the prognostic factors in breast cancer, and an indicator forhormonal treatment. 147 genes and 112 genes with significant P-value and havingsignificant differential expression between ER+ and ER− tumors were identified from theLCM data set and bulk tissue data set, respectively. 61 genes were found to be commonin both data sets, while 85 genes were unique to the LCM data set and 51 genes werepresent only in the bulk tumor data set. Pathway analysis with the 85 genes using GeneOntology suggested that genes involved in endocytosis, ceramide generation,Ras/ERK/Ark cascade, and JAT-STAT pathway may play roles related to ER. The geneprofiling with LCM-captured tumor cells provides a unique approach to characterize andstudy epithelial tumor cells and to gain an insight into signaling pathways associated withER.
申请人：Yixin Wang,Jack X. Yu,Yugiu Jiang,Fei Yang
地址：San Diego CA US,San Diego CA US,San Diego CA US,San Diego CA US
国籍：US,US,US,US
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