Diagnosis, severity prediction, and monitoring of

专利名称：Diagnosis, severity prediction, and

monitoring of disease by immunoassay offree activation peptides of pancreaticzymogens

发明人：Hermon-Taylor, John, Dept. of

Surgery,Austen, Brian Maxwell, Dept. ofSurgery

申请号：EP87306613.8申请日：19870727公开号：EP0258995A1公开日：19880309

摘要：Pancreatic disease can be diagnosed by assaying a patient's body fluid, e.g.serum or urine, for the activation peptides of pancreatic zymogens specifically cleaved byproteolysis during activation, (PAP) e.g. peptides including the sequence DK having thelysine as the carboxy terminus. When PAP is assayed for, the test provides a means fordistinguishing necrotising acute pancreatitis from oedematous acute pancreatitis,provides for diagnosis of chronic pancreatitis in exacerbation, and permits monitoring ofthe severity progress of the disease. Also described are antibodies having specificity forthe pancreatic activation peptides, as well as such peptides and antibodies which arelabelled with revealing agents and/or immobilised on solid supports, and their use indiagnostic test kits.

申请人：BIOSCIENCE INTERNATIONAL, INC.

地址：73 Rutland Street, Suite No. 1 P.O. Box 18-1507 Boston Massachusetts 02118 US

国籍：US

代理机构：Goldin, Douglas Michael

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