FUNCTIONALIZATION OF BIOMATERIALS TO CONTROL REGEN

专利名称：FUNCTIONALIZATION OF BIOMATERIALS

TO CONTROL REGENERATION ANDINFLAMMATION RESPONSES

发明人：LLAMAS, JABIER GALLEGO,KAPLAN, DAVID

L.,PANILAITIS, BRUCE

申请号：EP12862472申请日：20121231公开号：EP27971A4公开日：20150729

摘要：The inventions provided herein generally relate to compositions and methodsfor controlling response of immune cells to at least one stimulus or condition (e.g., butnot limited to, tissue damage, an implantable device and/or a cytokine) in vitro or in vivo.The compositions described herein comprise a biomaterial (e.g., a silk fibroin-basedmatrix) comprising at least one immune cell-modulating agent in an effective amountsufficient to selectively alter activation state of at least one type of immune cells (e.g.,but not limited to macrophages and dendritic cells). Accordingly, in some embodiments,the compositions and methods described herein can be used to selectively skewmacrophages to M1 phenotype and/or M2 phenotype and thereby control the

inflammatory and/or regenerative responses of the macrophages, e.g., to repair and/orregenerate a target tissue.

申请人：TRUSTEES OF TUFTS COLLEGE

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