专利名称：CHARACTERIZATION OF HYBRIDIZED
POLYMER MOLECULES BASED ONMONOMER-INTERFACE INTERACTIONS
发明人：DENISON, TIMOTHY, J.,SAUER,
ALEXIS,GOLOVCHENKO, JENE,MELLER,AMIT,BRANDIN, ERIC,BRANTON, DANIEL
申请号：EP00984086申请日：20001208公开号：EP1238275A4公开日：20070523
摘要：The invention relates to a method for detecting a double-stranded region in anucleic acid by (1) providing two separate, adjacent pools of a medium and an interfacebetween the two pools, the interface having a channel so dimensioned as to allowsequential monomer-by-monomer passage of a single-stranded nucleic acid, but not of adouble-stranded nucleic acid, from one pool to the other pool; (2) placing a nucleic acidpolymer in one of the two pools; and (3) taking measurements as each of the nucleotidemonomers of the single-stranded nucleic acid polymer passes through the channel so asto differentiate between nucleotide monomers that are hybridized to another nucleotidemonomer before entering the channel and nucleotide monomers that are not hybridizedto another nucleotide monomer before entering the channel.
申请人：PRESIDENT AND FELLOWS OF HARVARD COLLEGE
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