TREATMENT OF PSORIASIS WITH 11-CIS-RETINOIC ACID

专利名称：TREATMENT OF PSORIASIS WITH 11-CIS-RETINOIC ACID

发明人：BRAIMAN, Mark S.申请号：EP96915529.0申请日：19960506公开号：EP0824348A1公开日：19980225

摘要：The instant invention disclosed the method of alleviating psoriasis symptomscomprises administering 11-cis-retinoic acid, in an acceptable topical vehicle, directly topsoriasis involved areas of the body. The retinoic acid has a concentration of the 11-cisisomer of at least 10 % of the level of all the isomers, on a weight basis. The 11-cis-retinoic acid can be the reaction product of the ultraviolet illumination of a secondgeometric isomer of retinoic acid which differs from the 11-cis-retinoic acid only in the cis-trans isomer state of at least one of its four non-ring C=C double bonds. The secondisomer of retinoic acid is one of the following: all-trans; 7-cis; 9-cis; 13-cis; 7,9-dicis; 7,11-dicis; 9,11-dicis; 9,13-dicis; or 11,13-dicis. Alternatively, 11-cis retinoic acid is the reactionproduct of 11-cis retinaldehyde or 11-cis retinal with oxidizing agents such as

hypochlorite and resorcinol or mixtures thereof as oxidizing agents. The topical vehicleincludes at least one member selected from the group consisting of water, propyleneglycol, petrolatum, mineral oil, glycerin, and mixtures thereof.

申请人：BRAIMAN, Mark S.

地址：1618 Shady Grove Court Charlottesville, VA 22902-7218 US

国籍：US

代理机构：Paget, Hugh Charles Edward, et al

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