PEPTIDE SPECIFICITY OF ANTI-MYELIN BASIS PROTEIN A

专利名称：PEPTIDE SPECIFICITY OF ANTI-MYELIN

BASIS PROTEIN AND THE ADMINISTRATIONOF MYELIN BASIC PROTEIN PEPTIDES TOMULTIPLE SCLEROSIS PATIENTS

发明人：Kenneth G. Warren,Ingrid Catz申请号：US121196申请日：20080505

公开号：US20080242616A1公开日：20081002

专利附图：

摘要：Human myelin basic protein (h-MBP) has a molecular weight of 18.5 KD and

contains 170 amino acid residues. Synthetic peptides ranging in length from about 8 to 25residues and covering the entire length of the protein have been produced. Antibodies toh-MBP (anti-MBP) were found to be neutralized by the synthetic peptides, in vitro, whichspan the h-MBP from about amino acid residue 61 to about amino acid residue 106. Thepeptides, which cover both the amino (about residues 1 to 63) and carboxy (aboutresidues 117 to 162) terminals of h-MBP did not neutralize purified anti-MBP. Intrathecaladministration of peptide MBP(75-95), MBP(86-95), or MBP(82-98) produced completebinding-neutralization of free (F) anti-MBP with no change in bound (B) levels. A controlpeptide MBP35-58 had no effect on F or B anti-MBP levels. Intravenous administration ofMBP(75-95), MBP(86-95), or MBP(82-98) resulted in significant decline of F and B CSF anti-MBP levels. Administration of MBP synthetic peptides to MS patients either intrathecallyor intravenously did not have any adverse neurological effects and systemic

complications did not occur. The MBP epitope for MS anti-MBP has been localized to anarea between amino acid 86 and amino acid 95.

申请人：Kenneth G. Warren,Ingrid Catz

地址：Edmonton CA,Edmonton CA

国籍：CA,CA

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