Crosslinked polymer compositions and methods for t

专利名称：Crosslinked polymer compositions and

methods for their use

发明人：Rhee, Woonza M.申请号：EP06006313.8申请日：19961218公开号：EP1704878B1公开日：20130410

摘要：Crosslinked polymer compositions comprise a first synthetic polymer

containing multiple nucleophilic groups covalently bound to a second synthetic polymercontaining multiple electrophilic groups. The first synthetic polymer is preferably asynthetic polypeptide or a polyethylene glycol that has been modified to containmultiple nucleophilic groups, such as primary amino (-NH2) or thiol (-SH) groups. Thesecond synthetic polymer may be a hydrophilic or hydrophobic synthetic polymer whichcontains, or has been derivatized to contain, two or more electrophilic groups, such assuccinimidyl groups. The compositions may further comprise other components, such asnaturally occurring polysaccharides or proteins (such as glycosaminoglycans or collagen)and/or biologically active agents. Also disclosed are methods for using the crosslinkedpolymer compositions to effect adhesion between a first surface and a second surface; toeffect tissue augmentation; to prevent the formation of surgical adhesions; and to coat asurface of a synthetic implant.

申请人：ANGIODEVICE INTERNAT GMBH

地址：CH

国籍：CH

代理机构：Grünecker, Kinkeldey, Stockmair & Schwanhäusser

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