Materials and methods relating to the induction of

专利名称：Materials and methods relating to the

induction of apoptosis in target cells

发明人：Barbara Ann Spruce,Neil Donald

Perkins,Jayne Samson,Niall McTavish

申请号：US09720851申请日：19990629公开号：US07572762B1公开日：20090811

摘要：Compositions, methods, uses and assemblages for the preferential induction ofcell division cycle arrest and/or apoptosis, in a first population of cells compared to asecond population of cells employ either: (i) an opioid or opioid-like agent and an NF-κBactivating agent, which agents are other than the opioid-like agent trans-U50488 incombination with an NF-κB activating agent selected from etoposide and nocodazole; (ii)a ligand for a sigma receptor, or (iii) an opioid or opioid-like agent wherein the cells of thefirst population are other than tumor cells.

申请人：Barbara Ann Spruce,Neil Donald Perkins,Jayne Samson,Niall McTavish

地址：Perth GB,Dundee GB,Dundee GB,Tayport GB

国籍：GB,GB,GB,GB

代理机构：Dann, Dorfman, Herrell & Skillman

代理人：Robert C. Netter,Kathleen D. Rigaut

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