专利名称：Rapid Acting Drug Delivery Compositions发明人：Roderike Pohl,Solomon S. Steiner申请号：US11767698申请日：20070625
公开号：US20070235365A1公开日：20071011
专利附图：
摘要：Drug formulations for systemic drug delivery with improved stability and rapidonset of action are described herein. The formulations may be administered via buccaladministration, sublingual administration, pulmonary delivery, nasal administration,subcutaneous administration, rectal administration, vaginal administration, or ocular
administration. In the preferred embodiments, the formulations are administeredsublingually or via subcutaneous injection. The formulations contain an active agent andone or more excipients, selected to increase the rate of dissolution. In the preferredembodiment, the drug is insulin, and the excipients include a metal chelator such as EDTAand an acid such as citric acid. Following administration, these formulations are rapidlyabsorbed by the oral mucosa when administered sublingually and are rapidly absorbedinto the blood stream when administered by subcutaneous injection. In one embodiment,the composition is in the form of a dry powder. In another embodiment, the compositionis in the form of a film, wafer, lozenge, capsule, or tablet. In a third embodiment, a drypowdered insulin is mixed with a diluent containing a pharmaceutically acceptable carrier,such as water or saline, a metal chelator such as EDTA and an acid such as citric acid.Devices for storing and mixing these formulations are also described.
申请人：Roderike Pohl,Solomon S. Steiner
地址：Sherman CT US,Mount Kisco NY US
国籍：US,US
更多信息请下载全文后查看
因篇幅问题不能全部显示，请点此查看更多更全内容