Pyrrolobenzodiazepines

专利名称：Pyrrolobenzodiazepines发明人：Thurston, David Edwin, School of

Pharmacy,Howard, Philip Wilson, School ofPharmacy

申请号：EP01129700.9申请日：19990827公开号：EP1193270B1公开日：20030514

摘要：Compounds of the formulae Ia and Ib: wherein: A is CH2, or a single bond; R2 isselected from: R, OH, OR, CO2H, CO2R, COH, COR, SO2R, CN; R6, R7 and R9 areindependently selected from H, R, OH, OR, halo, amino, NHR, nitro, Me3Sn; and R8 isselected from H, R, OH, OR, halo, amino, NHR, nitro, Me3Sn, where R is as defined above,or the compound is a dimer with each monomer being the same or different and being offormula Ia or Ib, where the R8 groups of the monomers form together a bridge havingthe formula -X-R'-X- linking the monomers, where R' is an alkylene chain containing from3 to 12 carbon atoms, which chain may be interrupted by one or more hetero-atomsand/or aromatic rings and may contain one or more carbon-carbon double or triplebonds, and each X is independently selected from O, S, or N; except that in a compoundof formula Ia when A is a single bond, then R2 is not CH=CH(CONH2) orCH=CH(CONMe2). Other related compounds are also disclosed.

申请人：SPIROGEN LTD

地址：GB

国籍：GB

代理机构：Watson, Robert James

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