Compositions and methods for the treatment of dise

专利名称：Compositions and methods for the

treatment of diseases related to the renin-angiotensin-system

发明人：Marko Poglitsch,Cornelia Schwager,Hans

Loibner

申请号：US15103618申请日：20141211公开号：US09839668B2公开日：20171212

摘要：The present invention relates to a pharmaceutical composition comprising a. atleast one aspartyl aminopeptidase inhibitor and at least one angiotensin-converting-enzyme (ACE) inhibitor, or b. at least one aspartyl aminopeptidase inhibitor and at leastone chymase inhibitor. In an embodiment, the pharmaceutical composition comprises atleast one aspartyl aminopeptidase inhibitor and at least one angiotensin-converting-enzyme (ACE) inhibitor and at least one chymase inhibitor. Furthermore, the inventionrelates to a pharmaceutical composition possessing inhibitory activity against a. aspartylaminopeptidase and angiotensin-converting-enzyme (ACE), or b. against aspartylaminopeptidase and chymase. In a third aspect, the invention relates to a kit of partscomprising a. a pharmaceutical composition comprising an aspartyl aminopeptidaseinhibitor and a pharmaceutical composition comprising an angiotensin-converting-enzyme(ACE) inhibitor, or b. a pharmaceutical composition comprising an aspartyl

aminopeptidase inhibitor and a pharmaceutical composition comprising a chymaseinhibitor, or c. a pharmaceutical composition comprising an aspartyl aminopeptidase

inhibitor and a pharmaceutical composition comprising an angiotensin-converting-enzyme(ACE) inhibitor and a pharmaceutical composition comprising a chymase inhibitor. Theinvention also relates to a method for decreasing the blood pressure in a subject byadministering a therapeutically effective amount of a pharmaceutical compositionaccording to the invention to the subject. In another aspect, the invention relates to amethod for treating a disease related to the RAS in a subject by administering atherapeutically effective amount of a pharmaceutical composition according to theinvention to the subject.

申请人：ATTOQUANT DIAGNOSTICS GMBH

地址：Vienna AT

国籍：AT

代理机构：Norton Rose Fulbright US LLP

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