专利名称：Model predictive method and system for
controlling and supervising insulin infusion
发明人：Steil, Garry, M.,Kanderian, Sami, S.,
Jr.,Cantwell, Martin, T.,Hoss, Udo
申请号：EP11191158.2申请日：20071221公开号：EP2425774A1公开日：20120307
专利附图：
摘要：A system and method for controlling and monitoring a diabetes-managementsystem through the use of a model that predicts or estimates future dynamic states of
glucose and insulin from variables such as insulin delivery or exogenous glucose
appearance as well as inherent physiological parameters. The model predictive estimatorcan be used as an insulin bolus advisor to give an apriori estimate of postprandial glucosefor a given insulin delivery profile administered with a known meal to optimize insulindelivery; as a supervisor to monitor the operation of the diabetes-management system;and as a model predictive controller to optimize the automated delivery of insulin into auser's body to achieve a desired blood glucose profile or concentration. Open loop,closed-loop, and semi-closed loop embodiments of the invention utilize a mathematicalmetabolic model that includes a Minimal Model, a Pump Delivery to Plasma InsulinModel, and a Meal Appearance Rate Model.
申请人：Medtronic MiniMed, Inc.
地址：18000 Devonshire Street Northridge, CA 91325-1219 US
国籍：US
代理机构：Goddar, Heinz J.
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