PYRAZOLOPYRIDINE DERIVATIVES

专利名称：PYRAZOLOPYRIDINE DERIVATIVES发明人：JASON WITHERINGTON申请号：AU2003245700申请日：20030212

公开号：AU2003245700A1公开日：20030904

摘要：Certain compounds of formula (I), or a salt thereof, or a solvate thereof,wherein R1, R2, R3 and R4 are as defined in the specification, a procees for thepreparation of such compounds, a pharmaceutical composition comprising such

compounds and the use of such compounds in medicine. For the treatment of conditionsassociated with a need for inhibition of GSK-3 such as diabetes, conditions associated withdiabetes, chronic neurodegenerative conditions including dementias such as Alzheimer'sdisease, Parkinson's disease, progressive supranuclear palsy, subacute sclerosing

panencephalitic parkinsonism, postencephalitic parkinsonism, pugilistic encephalitis, guamparkinsonism-dementia complex, Picks's disease, corticobasal degeneration,

frontotemporal dementia, Huntingdon's disease, AIDS associated dementia, amyotrophiclateral sclerosis, multiple sclerosis and neurotraumatic diseases such as acute stroke,mood disorders such as schizophrenia and bipolar disorders, promotion of functionalrecovery post stroke, cerebral bleeding (for example, due to solidary cerebral amyloidangiopathy), hair loss, obesity, atherosclerotic cardiovascular disease, hypertension,polycystic ovary syndrome, syndrome X, ischaemia, traumatic brain injury, cancer,leukopenia, Down's syndrome, Lewy body disease, inflammation, and immunodeficiency.

申请人：GLAXO GROUP LIMITED

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