专利名称：Compositions and their uses directed to
PTPRU
发明人：Robert McKay,Ravi Jain,Kenneth W.
Dobie,Sanjay K. Pandey,Sanjay Bhanot
申请号：US11915309申请日：20060524公开号：US07897583B2公开日：20110301
摘要：Disclosed herein are compounds, compositions and methods for modulatingthe expression of PTPRU in a cell, tissue or animal. Also provided are methods of activetarget segment validation. Also provided are uses of disclosed compounds andcompositions in the manufacture of a medicament for treatment of diseases and
disorders. Also provided are methods for the prevention, amelioration and/or treatmentof diabetes, obesity, insulin resistance, insulin deficiency, hypercholesterolemia,
hyperglycemia, hyperlipidemia, hypertriglyceridemia, hyperfattyacidemia, liver steatosis,steatohepatitis, non-alcoholic steatohepatitis, metabolic syndrome, cardiovasculardisease and coronary heart disease by administration of antisense compounds targetedto PTPRU.
申请人：Robert McKay,Ravi Jain,Kenneth W. Dobie,Sanjay K. Pandey,Sanjay Bhanot
地址：Poway CA US,Carlsbad CA US,Del Mar CA US,Encinitas CA US,Carlsbad CA US
国籍：US,US,US,US,US
代理机构：Knobbe, Martens, Olson & Bear
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