PdtDtShtProduct Data SheetProduct Name:CAS No.: Cat. No.:MWt:Formula:Purity :Abacavir136470-78-5HY-17423286.33C14H18N6O>98%Solubility:DMSOMechanisms: Pathways:Anti-infection; Target:NRTIs Pathways:Anti-infection; Target:HIV Biological Activity:g()Abacavir is a powerful nucleoside analog reverse transcriptase inhibitor (NRTI) used to treat HIVand AIDS. IC50 value: Target: NRTI; reverse transcriptase inhibitor Abacavir is a nucleoside reverse transcriptase inhibitor marketed since 1999 for the treatment ofinfection with the human immunodeficiency virus type 1 (HIV). Despite its clinical efficacy, abacaviradministration has been associated with serious and sometimes fatal toxic events. Abacavir hasbeen reported to undergo bioactivation in vitro, yielding reactive species that bind covalently tohuman serum albumin, but the haptenation mechanism and its significance to the toxic eventsidinduced by this anti-HIV drug have yet to be elucidated. dbthitiHIVdhttblidtd The mechanism underlying abacavir hypersensitivity syndrome is related to the change in the HLA-B*5701 protein product. Abacavir binds with high specificity to the HLA-...References:[1]. Charneira C, et al. Reactive aldehyde metabolites from the anti-HIV drug abacavir: amino acidadducts as possible factors in abacavir toxicity. Chem Res Toxicol. 2011 Dec 19;24(12):2129-41. [2]HerveyPSetalAbacavir:areviewofitsclinicalpotentialinpatientswithHIVinfectionDrugs[2]. Hervey PS, et al. Abacavir: a review of its clinical potential in patients with HIV infection. Drugs.2000 Aug;60(2):447-79. Caution: Not fully tested. For research purposes onlyMedchemexpress LLCwww.medchemexpress.com