Preparation of an oral pharmaceutical formulation

专利名称：Preparation of an oral pharmaceutical

formulation containing an anti-infectiveagent and a microorganism

发明人：Rajiv Indravadan Modi,Yatish Kumar

Bansal,Bakulesh Mafatlal Khamar

申请号：US090450申请日：19980323公开号：US06306391B1公开日：20011023

摘要：A process of making a stable fixed dose oral pharmaceutical formulation isprovided. The formulation contains at least one anti-infective agent and at least onemicroorganism. The process involves a step of first coating the agent and/or the

microorganism to provide a protective barrier around it. Next, the process involves a stepof combining the agent and the microorganism into a single pharmaceutical formulationin the form of a capsule or a tablet. The barrier protects the microorganism from theeffect of the anti-infective agent to maintain the microorganism in a viable form for aperiod of at least three months. The agent can be an antibiotic such as amoxycillin andthe microorganism can be

申请人：CADILA PHARMACEUTICALS, LTD.

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