Substituted cinnamic acid guanidides, process for

专利名称：Substituted cinnamic acid guanidides,

process for their preparation, their use ascardiovascualr medicament or diagnosticagent, as well as medicament containingthem

发明人：SCHWARK, JAN-ROBERT,

DR.,BRENDEL,JOACHIM, DR.,KLEEMANN,HEINZ-WERNER, DR.,LANG, HANS-JOCHEN,DR.,WEICHERT, ANDREAS, DR.,ALBUS, UDO,DR.,SCHOLZ, WOLFGANG, DR.

申请号：EP96111665.4申请日：19960719公开号：EP0755919A3公开日：19970409

摘要：The Substd. of public formula (I) and their saltCinnamic acid guanidides are new:at least one of R1-R5=XaYbLnU; X=CR16R17, O, S or NR18; One=0-1; Y=1-8C alkenyls, 1-8C alkenyls-T, 1-8C alkenyls-T2; T=NR20, O, S or phenyl (pass through the opt. of 1-3 Fsubstd., Cl, CF3, CH3, OCH3 or NR21R22); b=0-1 ; L=O, S, NR23 or CkH2k; k=1-8 ; n=0-1 ;U=NR24R25 or 1-9C N- heterocycles have a N or C bridges and opt. substd., pass through1-3 F, Cl, CF3, CH3, OCH3 or NR27R28; 25=H of R24, R, 1-8C alkyl or 1-8C perfluoroalkyls;Or there is a CH2 opt.R24+R25=(CH2) x, by O, the replacement of S, NH, NMe or N-benzyl; Remaining R1-R5=H, F, Cl, Br, I, CN, OnCmH2m+1, operation (CH2) sCqF2q+1 orCrH2rR10; m=0-8 ; p=0-1 ; q=1-8 ; S, r=0-4; R10=3-8C naphthenic base or phenyl opt.

substd., pass through 1-3 F, Cl, CF3, CH3, OCH3 or NR11R12; R6, R7=H, F, Cl, Br, I, CN, 1-8Calkyl, 1-8C perfluoroalkyls, 3-8C naphthenic base, the phenyl substd. by 1-3 F, Cl, CF3,CH3, OCH3 or NR14R15; R11, R12, R14-R18, R20-R23, R27 and R28=H, 1-4C alkyl or 1-4Cperfluoroalkyls.

申请人：HOECHST AKTIENGESELLSCHAFT

地址：Brüningstrasse 50 65929 Frankfurt am Main DE

国籍：DE

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