专利名称：New markers for cancer
发明人：Skotheim, Rolf I.,Lothe, Ragnhild A.,Lind,
Guro E.,Ahlquist, Terje C.
申请号：EP12154273.2申请日：20080221公开号：EP2474628B1公开日：20151028
摘要：The present invention relates to novel markers for hypermethylation of genepromoters in cancers. In particular the present invention relates to a method ofdetermining whether a tumour is developing in the aero-digestive system, or whether asubject is relapsing after treatment of such a tumour. The method comprisesdetermining the methylation level, the number of methylated CpG sites or themethylation state of CpG sites in a nucleic acid sequence in the promoter region, firstexon or intron, of one or more genes selected from the group consisting of CNRIP1,MAL, FBN1, SPG20, SNCA, and INA. The method further relates to a diagnostic kit fordetecting tumours in the aero-digestive tract.
申请人：OSLO UNIVERSITETSSYKEHUS HF
地址：NO
国籍：NO
代理机构：Plougmann & Vingtoft A/S
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